Ontology highlight
ABSTRACT:
SUBMITTER: Bodhinathan K
PROVIDER: S-EPMC3933770 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Bodhinathan Karthik K Slesinger Paul A PA
Frontiers in physiology 20140225
Alcohol (ethanol)-induced behaviors may arise from direct interaction of alcohol with discrete protein cavities within brain proteins. Recent structural and biochemical studies have provided new insights into the mechanism of alcohol-dependent activation of G protein-gated inwardly rectifying potassium (GIRK) channels, which regulate neuronal responses in the brain reward circuit. GIRK channels contain an alcohol binding pocket formed at the interface of two adjacent channel subunits. Here, we d ...[more]