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Fabrication of magneto-controlled moveable architecture to develop reusable electrochemical biosensors.

ABSTRACT: Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcome this problem, we propose a novel concept by introducing a magneto-controlled moveable architecture (MCMA) instead of the conventional surface-fixed architecture. As a model, human breast cancer cells were used in this study. The results showed that a detection range from 100 to 1 × 10(6) cells could be achieved. Moreover, the whole detection cycle, including the measurement and the regeneration, could be completed in only 2 min. Thus, usability and excellent performance can be achieved in a single biosensor.

SUBMITTER: Zhu X

PROVIDER: S-EPMC3933910 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Fabrication of magneto-controlled moveable architecture to develop reusable electrochemical biosensors.

Zhu Xiaoli X Feng Chang C Ye Zonghuang Z Chen Yangyang Y Li Genxi G

Scientific reports 20140225

Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcome this problem, we propose a novel concept by introducing a magneto-controlled moveable architecture (MCMA) instead of the conventional surface-fixed architecture. As a model, human ...[more]

PMID: 24566810

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