Ontology highlight
ABSTRACT:
SUBMITTER: Tian X
PROVIDER: S-EPMC3934159 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Tian Xuefei X Kim Jin Ju JJ Monkley Susan M SM Gotoh Nanami N Nandez Ramiro R Soda Keita K Inoue Kazunori K Balkin Daniel M DM Hassan Hossam H Son Sung Hyun SH Lee Yashang Y Moeckel Gilbert G Calderwood David A DA Holzman Lawrence B LB Critchley David R DR Zent Roy R Reiser Jochen J Ishibe Shuta S
The Journal of clinical investigation 20140217 3
Podocytes are specialized actin-rich epithelial cells that line the kidney glomerular filtration barrier. The interface between the podocyte and the glomerular basement membrane requires integrins, and defects in either α3 or β1 integrin, or the α3β1 ligand laminin result in nephrotic syndrome in murine models. The large cytoskeletal protein talin1 is not only pivotal for integrin activation, but also directly links integrins to the actin cytoskeleton. Here, we found that mice lacking talin1 spe ...[more]