Ontology highlight
ABSTRACT:
SUBMITTER: Stephens DM
PROVIDER: S-EPMC3934299 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Stephens Deborah M DM Ruppert Amy S AS Maddocks Kami K Andritsos Leslie L Baiocchi Robert R Jones Jeffrey J Johnson Amy J AJ Smith Lisa L LL Zhao Yuan Y Ling Yonghua Y Li Junan J Phelps Mitch A MA Grever Michael R MR Byrd John C JC Flynn Joseph M JM
Leukemia research 20130715 10
Alvocidib has demonstrated efficacy in high-risk chronic lymphocytic leukemia (CLL) patients. In this phase I study, we combined cyclophosphamide, alvocidib and rituximab (CAR) in a schema designed to mitigate tumor lysis syndrome (TLS) seen previously with alvocidib. Nine nucleoside analog-naïve, high-risk patients received escalating doses of CAR therapy. Dose limiting toxicity was not experienced. No instances of TLS were observed. Patient responses included three complete remissions and four ...[more]