Ontology highlight
ABSTRACT:
SUBMITTER: Chaturvedi KS
PROVIDER: S-EPMC3934373 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Chaturvedi Kaveri S KS Hung Chia S CS Giblin Daryl E DE Urushidani Saki S Austin Anthony M AM Dinauer Mary C MC Henderson Jeffrey P JP
ACS chemical biology 20131211 2
Many Gram-negative bacteria interact with extracellular metal ions by expressing one or more siderophore types. Among these, the virulence-associated siderophore yersiniabactin (Ybt) is an avid copper chelator, forming stable cupric (Cu(II)-Ybt) complexes that are detectable in infected patients. Here we show that Ybt-expressing E. coli are protected from intracellular killing within copper-replete phagocytic cells. This survival advantage is highly dependent upon the phagocyte respiratory burst ...[more]