Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.
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ABSTRACT:
SUBMITTER: Huynh JL
PROVIDER: S-EPMC3934491 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.
Huynh Jimmy L JL Garg Paras P Thin Tin Htwe TH Yoo Seungyeul S Dutta Ranjan R Trapp Bruce D BD Haroutunian Vahram V Zhu Jun J Donovan Michael J MJ Sharp Andrew J AJ Casaccia Patrizia P
Nature neuroscience 20131124 1
Using the Illumina 450K array and a stringent statistical analysis with age and gender correction, we report genome-wide differences in DNA methylation between pathology-free regions derived from human multiple sclerosis-affected and control brains. Differences were subtle, but widespread and reproducible in an independent validation cohort. The transcriptional consequences of differential DNA methylation were further defined by genome-wide RNA-sequencing analysis and validated in two independen ...[more]
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