Ontology highlight
ABSTRACT:
SUBMITTER: Nalam MN
PROVIDER: S-EPMC3934494 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Nalam Madhavi N L MN Ali Akbar A Reddy G S Kiran Kumar GS Cao Hong H Anjum Saima G SG Altman Michael D MD Yilmaz Nese Kurt NK Tidor Bruce B Rana Tariq M TM Schiffer Celia A CA
Chemistry & biology 20130905 9
The rapid evolution of HIV under selective drug pressure has led to multidrug resistant (MDR) strains that evade standard therapies. We designed highly potent HIV-1 protease inhibitors (PIs) using the substrate envelope model, which confines inhibitors within the consensus volume of natural substrates, providing inhibitors less susceptible to resistance because a mutation affecting such inhibitors will simultaneously affect viral substrate processing. The designed PIs share a common chemical sca ...[more]