Ontology highlight
ABSTRACT:
SUBMITTER: Qiu Y
PROVIDER: S-EPMC3934934 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Qiu Yang Y Wang Zhaowei Z Liu Yongxiang Y Han Yajuan Y Miao Meng M Qi Nan N Yang Jie J Xia Hongjie H Li Xiaofeng X Qin Cheng-Feng CF Hu Yuanyang Y Zhou Xi X
PloS one 20140225 2
RNA replication of positive-strand (+)RNA viruses requires the protein-protein interactions among viral replicases and the association of viral replicases with intracellular membranes. Protein A from Wuhan nodavirus (WhNV), which closely associate with mitochondrial membranes, is the sole replicase required for viral RNA replication. Here, we studied the direct effects of mitochondrial membrane lipids (MMLs) on WhNV protein A activity in vitro. Our investigations revealed the self-interaction of ...[more]