Ontology highlight
ABSTRACT:
SUBMITTER: Dhillon MS
PROVIDER: S-EPMC3935203 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Dhillon Mandeep S MS Cockcroft Christopher J CJ Munsey Tim T Smith Kathrine J KJ Powell Andrew J AJ Carter Paul P Wrighton David C DC Rong Hong-lin HL Yusaf Shahnaz P SP Sivaprasadarao Asipu A
Scientific reports 20140226
Members of the six-transmembrane segment family of ion channels share a common structural design. However, there are sequence differences between the members that confer distinct biophysical properties on individual channels. Currently, we do not have 3D structures for all members of the family to help explain the molecular basis for the differences in their biophysical properties and pharmacology. This is due to low-level expression of many members in native or heterologous systems. One excepti ...[more]