Ontology highlight
ABSTRACT:
SUBMITTER: Markson JS
PROVIDER: S-EPMC3935230 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Cell 20131201 6
The cyanobacterial circadian clock generates genome-wide transcriptional oscillations and regulates cell division, but the underlying mechanisms are not well understood. Here, we show that the response regulator RpaA serves as the master regulator of these clock outputs. Deletion of rpaA abrogates gene expression rhythms globally and arrests cells in a dawn-like expression state. Although rpaA deletion causes core oscillator failure by perturbing clock gene expression, rescuing oscillator functi ...[more]