Ontology highlight
ABSTRACT:
SUBMITTER: Hobson SA
PROVIDER: S-EPMC3935412 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Hobson Sally-Ann SA Vanderplank Penny A PA Pope Robert J P RJ Kerr Niall C H NC Wynick David D
Journal of neurochemistry 20130822 2
We and others have previously shown that the neuropeptide galanin modulates neurite outgrowth from adult sensory neurons via activation of the second galanin receptor; however, the intracellular signalling pathways that mediate this neuritogenic effect have yet to be elucidated. Here, we demonstrate that galanin decreases the activation state in adult sensory neurons and PC12 cells of Rho and Cdc42 GTPases, both known regulators of filopodial and growth cone motility. Consistent with this, activ ...[more]