Dataset Information

Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey.

ABSTRACT:

Background

Herpesviruses have been linked to cognitive impairment in older individuals but little is known about the association in the general US population.

Methods

We determined whether cytomegalovirus (CMV) and herpes simplex virus 1 (HSV-1) seropositivity were associated with cognitive impairment among children (aged 6-16 years) and adults aged 20-59 or ?60 years, using data from the National Health and Nutrition Examination Survey (NHANES) III. Linear and logistic regression models were used to examine the associations between pathogen seropositivity and cognitive impairment.

Results

Among children, HSV-1 seropositivity was associated with lower reading and spatial reasoning test scores (?, -0.69; 95% confidence interval [CI], -1.18 to -.21 and ?, -0.82; 95% CI, -1.29 to -.36, respectively). Among middle-aged adults, HSV-1 and CMV seropositivity were associated with impaired coding speed (odds ratio [OR], 1.54; 95% CI, 1.13-2.11, and OR, 1.41; 95% CI, 1.09-1.82, respectively). CMV seropositivity was also associated with impaired learning and recall (OR, 1.43; 95% CI, 1.14-1.80). Among older adults, HSV-1 seropositivity was associated with immediate memory impairment (OR, 3.26; 95% CI, 1.68-6.32).

Conclusions

Future studies examining the biological pathways by which herpesviruses influence cognitive impairment across the life course are warranted.

SUBMITTER: Tarter KD

PROVIDER: S-EPMC3935478 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Publications

Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey.

Tarter Kara D KD Simanek Amanda M AM Dowd Jennifer B JB Aiello Allison E AE

The Journal of infectious diseases 20131118 6

<h4>Background</h4>Herpesviruses have been linked to cognitive impairment in older individuals but little is known about the association in the general US population.<h4>Methods</h4>We determined whether cytomegalovirus (CMV) and herpes simplex virus 1 (HSV-1) seropositivity were associated with cognitive impairment among children (aged 6-16 years) and adults aged 20-59 or ≥60 years, using data from the National Health and Nutrition Examination Survey (NHANES) III. Linear and logistic regression ...[more]

PMID: 24253286

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Project description:BACKGROUND: The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. METHODS: Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). RESULTS: Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. In non-Hispanic whites, no individual polymorphisms were associated with any lipid trait. However, the PON1 A-G haplotype was significantly associated with LDL-C and TC. In non-Hispanic blacks, APOE variant rs7412 and haplotype T-T were strongly associated with LDL-C and TC; whereas, rs5918 of ITGB3 was significantly associated with TG. Several variants and haplotypes of three genes were significantly related to lipids in Mexican Americans: PON1 in relation to HDL-C; APOE and NOS3 in relation to LDL-C; and APOE in relation to TC. CONCLUSIONS: We report the significant associations of blood lipids with variants and haplotypes in APOE, ITGB3, NOS3, and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations.

Dataset Information

Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey.

Background

Methods

Results

Conclusions

Publications

Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey.

Similar Datasets

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