Unknown

Dataset Information

0

Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication.


ABSTRACT: It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (doxorubicin) (I/D-Micelles) as a novel theranostic platform with high drug loading, good stability and enhanced cellular uptake via clathrin-mediated endocytosis. I/D-Micelles exhibit the multiple functionalities including near-infrared fluorescence (NIRF), hyperthermia and intracellular singlet oxygen from indocyanine green, and simultaneous cytotoxicity from doxorubicin. Upon photoirradiation, I/D-Micelles can induce NIRF imaging, acute photothermal therapy via hyperthermia and simultaneous synergistic chemotherapy via singlet oxygen-triggered disruption of lysosomal membranes, eventually leading to enhanced NIRF imaging and superior tumor eradication without any re-growth. Our results suggest that the hierarchical micelles can act as a superior theranostic platform for cancer imaging and multimodal synergistic therapy.

SUBMITTER: Wan Z 

PROVIDER: S-EPMC3936292 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

altmetric image

Publications

Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication.

Wan Zhihui Z   Mao Huajian H   Guo Miao M   Li Yanli Y   Zhu Aijun A   Yang Hong H   He Hui H   Shen Junkang J   Zhou Lijuan L   Jiang Zhen Z   Ge Cuicui C   Chen Xiaoyuan X   Yang Xiangliang X   Liu Gang G   Chen Huabing H  

Theranostics 20140129 4


It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (doxorubicin) (I/D-Micelles) as a novel theranostic platform with high drug loading, good stability and enhanced cellular uptake via clathrin-mediated endocytosis. I/D-Micelles exhibit the multiple func  ...[more]

Similar Datasets

| S-EPMC6406889 | biostudies-literature
| S-EPMC11015563 | biostudies-literature
| S-EPMC5915677 | biostudies-literature
| S-EPMC8706488 | biostudies-literature
| S-EPMC8607732 | biostudies-literature
| S-EPMC6135792 | biostudies-literature
2012-04-03 | GSE33548 | GEO
| S-EPMC3309399 | biostudies-literature
| S-EPMC3356615 | biostudies-literature
| S-EPMC6858316 | biostudies-literature