Cuprizone short-term exposure: astrocytic IL-6 activation and behavioral changes relevant to psychosis.
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ABSTRACT:
SUBMITTER: Tezuka T
PROVIDER: S-EPMC3936339 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Cuprizone short-term exposure: astrocytic IL-6 activation and behavioral changes relevant to psychosis.
Tezuka Tomoaki T Tamura Makoto M Kondo Mari A MA Sakaue Masaki M Okada Kinya K Takemoto Kana K Fukunari Atsushi A Miwa Keiko K Ohzeki Hiromitsu H Kano Shin-ichi S Yasumatsu Hiroshi H Sawa Akira A Kajii Yasushi Y
Neurobiology of disease 20130716
A growing body of evidence suggests the involvement of inflammatory processes in the pathophysiology of schizophrenia. Four- to 8-week exposure to cuprizone, a copper chelator, causes robust demyelination and has been used to build a model for multiple sclerosis. In contrast, we report here the effects of 1-week cuprizone exposure in mice. This short-term cuprizone exposure elicits behavioral changes that include augmented responsiveness to methamphetamine and phencyclidine, as well as impaired ...[more]
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