Ontology highlight
ABSTRACT:
SUBMITTER: Yang JY
PROVIDER: S-EPMC3936340 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Yang Jane Y JY Sanchez Laura M LM Rath Christopher M CM Liu Xueting X Boudreau Paul D PD Bruns Nicole N Glukhov Evgenia E Wodtke Anne A de Felicio Rafael R Fenner Amanda A Wong Weng Ruh WR Linington Roger G RG Zhang Lixin L Debonsi Hosana M HM Gerwick William H WH Dorrestein Pieter C PC
Journal of natural products 20130911 9
A major goal in natural product discovery programs is to rapidly dereplicate known entities from complex biological extracts. We demonstrate here that molecular networking, an approach that organizes MS/MS data based on chemical similarity, is a powerful complement to traditional dereplication strategies. Successful dereplication with molecular networks requires MS/MS spectra of the natural product mixture along with MS/MS spectra of known standards, synthetic compounds, or well-characterized or ...[more]