Ontology highlight
ABSTRACT:
SUBMITTER: Strunk RJ
PROVIDER: S-EPMC3936449 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Strunk Robert J RJ Piemonte Katrina M KM Petersen Natasha M NM Koutsioulis Dimitris D Bouriotis Vassilis V Perry Kay K Cole Kathryn E KE
Acta crystallographica. Section F, Structural biology communications 20140121 Pt 2
Polysaccharide deacetylases are bacterial enzymes that catalyze the deacetylation of acetylated sugars on the membranes of Gram-positive bacteria, allowing them to be unrecognized by host immune systems. Inhibition of these enzymes would disrupt such pathogenic defensive mechanisms and therefore offers a promising route for the development of novel antibiotic therapeutics. Here, the first X-ray crystal structure of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis, is reporte ...[more]