Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC3936745 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Zhang Xiaojun X Dantas Machado Ana Carolina AC Ding Yuan Y Chen Yongheng Y Lu Yan Y Duan Yankun Y Tham Kenneth W KW Chen Lin L Rohs Remo R Qin Peter Z PZ
Nucleic acids research 20131130 4
The tumor suppressor protein p53 regulates numerous signaling pathways by specifically recognizing diverse p53 response elements (REs). Understanding the mechanisms of p53-DNA interaction requires structural information on p53 REs. However, such information is limited as a 3D structure of any RE in the unbound form is not available yet. Here, site-directed spin labeling was used to probe the solution structures of REs involved in p53 regulation of the p21 and Bax genes. Multiple nanometer distan ...[more]