Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC3936760 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Lee Seung Hwan SH Oh Jungsic J Park Jonghyun J Paek Ki Young KY Rho Sangchul S Jang Sung Key SK Lee Jong-Bong JB
Nucleic acids research 20131129 4
When bound to the 3' poly(A) tail of mRNA, poly(A)-binding protein (PABP) modulates mRNA translation and stability through its association with various proteins. By visualizing individual PABP molecules in real time, we found that PABP, containing four RNA recognition motifs (RRMs), adopts a conformation on poly(A) binding in which RRM1 is in proximity to RRM4. This conformational change is due to the bending of the region between RRM2 and RRM3. PABP-interacting protein 2 actively disrupts the b ...[more]