Ontology highlight
ABSTRACT:
SUBMITTER: Balland E
PROVIDER: S-EPMC3936883 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Cell metabolism 20140201 2
Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR) in median eminence tanycytes followed by MBH neurons, a process requiring tanycytic ERK signaling and the passage of leptin through the cerebrospinal fluid. In mice lacking the signal-transducing Le ...[more]