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A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.


ABSTRACT: Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.

SUBMITTER: Matsen FA 

PROVIDER: S-EPMC3937129 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.

Matsen Frederick A FA   Small Christopher T CT   Soliven Khanh K   Engel Gregory A GA   Feeroz Mostafa M MM   Wang Xiaoxing X   Craig Karen L KL   Hasan M Kamrul MK   Emerman Michael M   Linial Maxine L ML   Jones-Engel Lisa L  

PLoS computational biology 20140227 2


Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity i  ...[more]

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