Ontology highlight
ABSTRACT:
SUBMITTER: Matsen FA
PROVIDER: S-EPMC3937129 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Matsen Frederick A FA Small Christopher T CT Soliven Khanh K Engel Gregory A GA Feeroz Mostafa M MM Wang Xiaoxing X Craig Karen L KL Hasan M Kamrul MK Emerman Michael M Linial Maxine L ML Jones-Engel Lisa L
PLoS computational biology 20140227 2
Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity i ...[more]