Isotype-specific inhibition of the phosphatidylinositol-3-kinase pathway in hematologic malignancies.
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ABSTRACT:
SUBMITTER: Castillo JJ
PROVIDER: S-EPMC3937185 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Isotype-specific inhibition of the phosphatidylinositol-3-kinase pathway in hematologic malignancies.
Castillo Jorge J JJ Iyengar Meera M Kuritzky Benjamin B Bishop Kenneth D KD
OncoTargets and therapy 20140221
In the last decade, the advent of biological targeted therapies has revolutionized the management of several types of cancer, especially in the realm of hematologic malignancies. One of these pathways, and the center of this review, is the phosphatidylinositol-3-kinase (PI3K) pathway. The PI3K pathway seems to play an important role in the pathogenesis and survival advantage in hematologic malignancies, such as leukemia, lymphoma, and myeloma. The objectives of the present review, hence, are to ...[more]
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