Ontology highlight
ABSTRACT:
SUBMITTER: Zemljic-Harpf AE
PROVIDER: S-EPMC3937777 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Zemljic-Harpf Alice E AE Godoy Joseph C JC Platoshyn Oleksandr O Asfaw Elizabeth K EK Busija Anna R AR Domenighetti Andrea A AA Ross Robert S RS
Journal of cell science 20140110 Pt 5
Vinculin (Vcl) links actin filaments to integrin- and cadherin-based cellular junctions. Zonula occludens-1 (ZO-1, also known as TJP1) binds connexin-43 (Cx43, also known as GJA1), cadherin and actin. Vcl and ZO-1 anchor the actin cytoskeleton to the sarcolemma. Given that loss of Vcl from cardiomyocytes causes maldistribution of Cx43 and predisposes cardiomyocyte-specific Vcl-knockout mice with preserved heart function to arrhythmia and sudden death, we hypothesized that Vcl and ZO-1 interact a ...[more]