Ontology highlight
ABSTRACT:
SUBMITTER: Coleman JA
PROVIDER: S-EPMC3937779 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Coleman Jonathan A JA Zhu Xianjun X Djajadi Hidayat R HR Molday Laurie L LL Smith Richard S RS Libby Richard T RT John Simon W M SW Molday Robert S RS
Journal of cell science 20140110 Pt 5
ATP8A2 is a P4-ATPase that is highly expressed in the retina, brain, spinal cord and testes. In the retina, ATP8A2 is localized in photoreceptors where it uses ATP to transport phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the exoplasmic to the cytoplasmic leaflet of membranes. Although mutations in ATP8A2 have been reported to cause mental retardation in humans and degeneration of spinal motor neurons in mice, the role of ATP8A2 in sensory systems has not been investigated. We ...[more]