Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC3938169 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Chen Ting T Takrouri Khuloud K Hee-Hwang Sung S Rana Sandeep S Yefidoff-Freedman Revital R Halperin Jose J Natarajan Amarnath A Morisseau Christophe C Hammock Bruce B Chorev Michael M Aktas Bertal H BH
Journal of medicinal chemistry 20131127 23
Heme-regulated inhibitor kinase (HRI), a eukaryotic translation initiation factor 2 alpha (eIF2α) kinase, plays critical roles in cell proliferation, differentiation, and adaptation to cytoplasmic stress. HRI is also a critical modifier of hemoglobin disorders such as β-thalassemia. We previously identified N,N'-diarylureas as potent activators of HRI suitable for studying the biology of this important kinase. To expand the repertoire of chemotypes that activate HRI, we screened a ∼1900 member N ...[more]