Ontology highlight
ABSTRACT:
SUBMITTER: Lien F
PROVIDER: S-EPMC3938262 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lien Fleur F Berthier Alexandre A Bouchaert Emmanuel E Gheeraert Céline C Alexandre Jeremy J Porez Geoffrey G Prawitt Janne J Dehondt Hélène H Ploton Maheul M Colin Sophie S Lucas Anthony A Patrice Alexandre A Pattou François F Diemer Hélène H Van Dorsselaer Alain A Rachez Christophe C Kamilic Jelena J Groen Albert K AK Staels Bart B Lefebvre Philippe P
The Journal of clinical investigation 20140217 3
The nuclear bile acid receptor farnesoid X receptor (FXR) is an important transcriptional regulator of bile acid, lipid, and glucose metabolism. FXR is highly expressed in the liver and intestine and controls the synthesis and enterohepatic circulation of bile acids. However, little is known about FXR-associated proteins that contribute to metabolic regulation. Here, we performed a mass spectrometry-based search for FXR-interacting proteins in human hepatoma cells and identified AMPK as a coregu ...[more]