Ontology highlight
ABSTRACT:
SUBMITTER: Azevedo OG
PROVIDER: S-EPMC3938486 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Azevedo Orleâncio G R OG Bolick David T DT Roche James K JK Pinkerton Relana F RF Lima Aldo A M AA Vitek Michael P MP Warren Cirle A CA Oriá Reinaldo B RB Guerrant Richard L RL
PloS one 20140228 2
Apolipoliprotein E (apoE), a critical targeting protein in lipid homeostasis, has been found to have immunoinflammatory effects on murine models of infection and malnutrition. The effects of apoE in undernourished and Cryptosporidium parvum-infected mice have not been investigated. In order to study the role of apoE in a model of C. parvum infection, we used the following C57BL6J mouse genetic strains: APOE-deficient, wild-type controls, and APOE targeted replacement (TR) mice expressing human A ...[more]