Ontology highlight
ABSTRACT:
SUBMITTER: Chen YZ
PROVIDER: S-EPMC3939056 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
During apoptosis, phosphatidylserine (PS), normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and serves as an 'eat-me' signal to trigger phagocytosis. It is poorly understood how PS exposure is activated in apoptotic cells. Here we report that CED-8, a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis and a homologue of the XK family proteins, is a substrate of the CED-3 caspase. Cleavage of CED-8 by CED ...[more]