Ontology highlight
ABSTRACT:
SUBMITTER: Das SK
PROVIDER: S-EPMC3939082 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Das Swadesh K SK Bhutia Sujit K SK Sokhi Upneet K UK Azab Belal B Su Zhao-Zhong ZZ Boukerche Habib H Anwar Talha T Moen Erika L EL Chatterjee Devasis D Pellecchia Maurizio M Sarkar Devanand D Fisher Paul B PB
Cancer research 20121011 23
Melanoma differentiation associated gene-9 (MDA-9), also known as syntenin, functions as a positive regulator of melanoma progression and metastasis. In contrast, the Raf kinase inhibitor, RKIP, a negative modulator of RAF-stimulated MEKK activation, is strongly downregulated in metastatic melanoma cells. In this study, we explored a hypothesized inverse relationship between MDA-9 and RKIP in melanoma. Tumor array and cell line analyses confirmed an inverse relationship between expression of MDA ...[more]