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Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia.

ABSTRACT: BACKGROUND:In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. METHODS:Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. RESULTS:Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. CONCLUSIONS:No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant.

SUBMITTER: Delaunay J

PROVIDER: S-EPMC3939385 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia.

Delaunay Jacques J Mazur Grzegorz G Minden Mark M Wierzbowska Agnieszka A Jones Mark M MM Berrak Erhan E Kantarjian Hagop M HM

Leukemia research reports 20131227 1

<h4>Background</h4>In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response.<h4>Methods</h4>Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders.<h4>Results</h4>Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data sh ...[more]

PMID: 24596676

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