Pancreatic cancer cachexia: a review of mechanisms and therapeutics.
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ABSTRACT:
SUBMITTER: Tan CR
PROVIDER: S-EPMC3939686 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Pancreatic cancer cachexia: a review of mechanisms and therapeutics.
Tan Carlyn R CR Yaffee Patrick M PM Jamil Laith H LH Lo Simon K SK Nissen Nicholas N Pandol Stephen J SJ Tuli Richard R Hendifar Andrew E AE
Frontiers in physiology 20140303
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology a ...[more]
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