Ontology highlight
ABSTRACT:
SUBMITTER: Ray S
PROVIDER: S-EPMC3939921 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Ray Sujay S Bandaria Jigar N JN Qureshi Mohammad H MH Yildiz Ahmet A Balci Hamza H
Proceedings of the National Academy of Sciences of the United States of America 20140210 8
Human telomeres terminate with a single-stranded 3' G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA binding. The G overhang spontaneously folds into various G-quadruplex (GQ) conformations. It remains unclear whether GQ formation affects the ability of POT1/TPP1 to compete against ...[more]