Ontology highlight
ABSTRACT:
SUBMITTER: Sethi M
PROVIDER: S-EPMC3940272 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Sethi Manish M Sukumar Rohit R Karve Shrirang S Werner Michael E ME Wang Edina C EC Moore Dominic T DT Kowalczyk Sonya R SR Zhang Liangfang L Wang Andrew Z AZ
Nanoscale 20140114 4
The effects of nanoparticle (NP) properties, such as size, shape and surface charge, on their efficacy and toxicity have been studied extensively. However, the effect of controlled drug release on NP efficacy and toxicity has not been thoroughly evaluated in vivo. Our study aims to fill this knowledge gap. A key challenge in characterizing the relationship between drug release and therapeutic ratio is to fabricate NPs that differ only in their drug release profile but are otherwise identical. To ...[more]