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Molecular architecture of tailed double-stranded DNA phages.


ABSTRACT: The tailed double-stranded DNA bacteriophages, or Caudovirales, constitute ~96% of all the known phages. Although these phages come in a great variety of sizes and morphology, their virions are mainly constructed of similar molecular building blocks via similar assembly pathways. Here we review the structure of tailed double-stranded DNA bacteriophages at a molecular level, emphasizing the structural similarity and common evolutionary origin of proteins that constitute these virions.

SUBMITTER: Fokine A 

PROVIDER: S-EPMC3940491 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Molecular architecture of tailed double-stranded DNA phages.

Fokine Andrei A   Rossmann Michael G MG  

Bacteriophage 20140101 1


The tailed double-stranded DNA bacteriophages, or <i>Caudovirales</i>, constitute ~96% of all the known phages. Although these phages come in a great variety of sizes and morphology, their virions are mainly constructed of similar molecular building blocks via similar assembly pathways. Here we review the structure of tailed double-stranded DNA bacteriophages at a molecular level, emphasizing the structural similarity and common evolutionary origin of proteins that constitute these virions. ...[more]

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