Ontology highlight
ABSTRACT:
SUBMITTER: Das S
PROVIDER: S-EPMC3940659 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Das Swagata S Pal Uttam U Das Supriya S Bagga Khyati K Roy Anupam A Mrigwani Arpita A Maiti Nakul C NC
PloS one 20140303 3
An amyloidogenic region (AR) in a protein sequence plays a significant role in protein aggregation and amyloid formation. We have investigated the sequence complexity of AR that is present in intrinsically disordered human proteins. More than 80% human proteins in the disordered protein databases (DisProt+IDEAL) contained one or more ARs. With decrease of protein disorder, AR content in the protein sequence was decreased. A probability density distribution analysis and discrete analysis of AR se ...[more]