Ontology highlight
ABSTRACT:
SUBMITTER: McNamara CW
PROVIDER: S-EPMC3940870 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
McNamara Case W CW Lee Marcus Cs MC Lim Chek Shik CS Lim Siau Hoi SH Roland Jason J Simon Oliver O Yeung Bryan Ks BK Chatterjee Arnab K AK McCormack Susan L SL Manary Micah J MJ Zeeman Anne-Marie AM Dechering Koen J KJ Kumar Tr Santha TS Henrich Philipp P PP Gagaring Kerstin K Ibanez Maureen M Kato Nobutaka N Kuhen Kelli L KL Fischli Christoph C Nagle Advait A Rottmann Matthias M Plouffe David M DM Bursulaya Badry B Meister Stephan S Rameh Lucia L Trappe Joerg J Haasen Dorothea D Timmerman Martijn M Sauerwein Robert W RW Suwanarusk Rossarin R Russell Bruce B Renia Laurent L Nosten Francois F Tully David C DC Kocken Clemens Hm CH Glynne Richard J RJ Bodenreider Christophe C Fidock David A DA Diagana Thierry T TT Winzeler Elizabeth A EA
Nature 20131127 7479
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as the target of imidazopyrazines, a new antimalarial compound class that inhibits the intracellular development of multiple Plasmodium species at each stage of infection in the vertebrate host. Imidazopyrazines demonstrate potent preventive, therapeutic, and transmission-blocking activity in rodent ma ...[more]