Ontology highlight
ABSTRACT:
SUBMITTER: van Heeringen SJ
PROVIDER: S-EPMC3941105 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
van Heeringen Simon J SJ Akkers Robert C RC van Kruijsbergen Ila I Arif M Asif MA Hanssen Lars L P LL Hanssen Lars L P LL Sharifi Nilofar N Veenstra Gert Jan C GJ
Genome research 20131211 3
During embryonic development, maintenance of cell identity and lineage commitment requires the Polycomb-group PRC2 complex, which catalyzes histone H3 lysine 27 trimethylation (H3K27me3). However, the developmental origins of this regulation are unknown. Here we show that H3K27me3 enrichment increases from blastula stages onward in embryos of the Western clawed frog (Xenopus tropicalis) within constrained domains strictly defined by sequence. Strikingly, although PRC2 also binds widely to active ...[more]