Ontology highlight
ABSTRACT:
SUBMITTER: Skokowa J
PROVIDER: S-EPMC3941918 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Skokowa Julia J Klimiankou Maxim M Klimenkova Olga O Lan Dan D Gupta Kshama K Hussein Kais K Carrizosa Esteban E Kusnetsova Inna I Li Zhixiong Z Sustmann Claudio C Ganser Arnold A Zeidler Cornelia C Kreipe Hans-Heinrich HH Burkhardt Janis J Grosschedl Rudolf R Welte Karl K
Nature medicine 20120923 10
We found that hematopoietic cell-specific Lyn substrate 1 (HCLS1 or HS1) is highly expressed in human myeloid cells and that stimulation with granulocyte colony-stimulating factor (G-CSF) leads to HCLS1 phosphorylation. HCLS1 binds the transcription factor lymphoid-enhancer binding factor 1 (LEF-1), transporting LEF-1 into the nucleus upon G-CSF stimulation and inducing LEF-1 autoregulation. In patients with severe congenital neutropenia, inherited mutations in the gene encoding HCLS1-associated ...[more]