Dataset Information

Correlations of pituitary tumor transforming gene expression with human pituitary adenomas: a meta-analysis.

ABSTRACT:

Objective

Pituitary tumor transforming gene (PTTG) is an important paracrine growth factor involved in early lactotrope transformation and early onset of angiogenesis in pituitary hyperplasia. Emerging evidences have shown that PTTG expression may contribute to the etiology of pituitary adenomas; but individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the correlations of PTTG expression with human pituitary adenomas.

Methods

A range of electronic databases were searched: MEDLINE (1966?2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980?2013), CINAHL (1982?2013), Web of Science (1945?2013) and the Chinese Biomedical Database (CBM) (1982?2013) without language restrictions. Meta-analysis was performed using the STATA 12.0 software. Crude odds ratio (OR) or standard mean difference (SMD) with its corresponding 95% confidence interval (95%CI) were calculated.

Results

Twenty-four clinical cohort studies were included with a total of 1,464 pituitary adenomas patients. The meta-analysis results revealed that patients with invasive pituitary adenomas had higher positive expression of PTTG than those of non-invasive patients (OR ?=?6.68, 95%CI ?=?3.72-11.99, P<0.001). We also found a significant difference in microvessel density between invasive and non-invasive patients (SMD ?=?1.81, 95%CI ?=?0.39-3.23, P?=?0.013). However, there were no significant difference in PTTG expression between functional and non-functional patients with pituitary adenomas (OR ?=?1.11, 95%CI ?=?0.58-2.10, P?=?0.753). No publication bias was detected in this meta-analysis (all P>0.05).

Conclusion

This present meta-analysis suggests that PTTG expression may be associated with tumor invasiveness and microvessel density of pituitary adenomas, while no correlations with functional status was found.

SUBMITTER: Xiao JQ

PROVIDER: S-EPMC3942425 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Correlations of pituitary tumor transforming gene expression with human pituitary adenomas: a meta-analysis.

Xiao Jian-Qi JQ Liu Xiao-Hai XH Hou Bo B Yao Yong Y Deng Kan K Feng Min M Xing Bin B Lian Wei W Wang Ren-Zhi RZ Feng Feng F

PloS one 20140304 3

<h4>Objective</h4>Pituitary tumor transforming gene (PTTG) is an important paracrine growth factor involved in early lactotrope transformation and early onset of angiogenesis in pituitary hyperplasia. Emerging evidences have shown that PTTG expression may contribute to the etiology of pituitary adenomas; but individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the correlations of PTTG expression with human pituitary adenomas. ...[more]

PMID: 24594688

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Project description:Objective: Epidermal growth factor receptor (EGFR) has been found to localize in several human neoplasms and has been shown to have a significant correlation with adenomaigenesis and patient prognosis. EGFR is also overexpressed in pituitary corticotroph adenomas. However, its clinical significance and relationship with tumor behavior, especially tumor recurrence status, remain obscure. The purpose of the present study was to identify the expression patterns of EGFR and its downstream signaling pathway molecules in pituitary corticotroph adenomas and to investigate the association of EGFR with clinicopathological characteristics and tumor recurrence. Methods: Fifty-two sporadic pituitary adenoma specimens and six normal pituitary glands were collected. The expression levels of EGFR and its downstream signaling molecules in each sample were evaluated and quantified using immunohistochemistry and Western blot. The relationships of EGFR expression with clinicopathological characteristics and tumor recurrence status were analyzed. Results: EGFR was overexpressed in 55.8% of the pituitary corticotroph adenomas and in 1 of 6 of the normal adenohypophysial tissues. The expression degree was significantly higher in pituitary corticotroph adenomas than in normal adenohypophysial tissues. In EGFR-overexpressing adenomas, the downstream pathway phosphorylated Erk (p-Erk) was also significantly activated. Moreover, the expression levels of EGFR were positively correlated with the adrenocorticotropic hormone (ACTH) and cortisol levels but were not correlated with age, sex or symptom duration. The expression levels of EGFR, phosphorylated EGFR (p-EGFR) and p-Erk were significantly up-regulated in the recurrent adenoma group compared with those in the non-recurrent adenoma group (all p < 0.05). The expression levels of EGFR were strongly correlated with the recurrence-free interval (p = 0.005, CC = -0.31). Conclusion: The expression levels of EGFR and its downstream pathway components were significantly increased in pituitary corticotroph adenomas compared to the levels in normal adenohypophysial tissues. EGFR expression levels were positively associated with the ACTH and cortisol levels and with tumor recurrence status. Pituitary corticotroph adenomas with high EGFR expression levels were correlated with an increased recurrence rate and a decreased recurrence-free interval. EGFR could be used as a promising biomarker for predicting pituitary corticotroph tumor recurrence.

Dataset Information

Correlations of pituitary tumor transforming gene expression with human pituitary adenomas: a meta-analysis.

Objective

Methods

Results

Conclusion

Publications

Correlations of pituitary tumor transforming gene expression with human pituitary adenomas: a meta-analysis.

Similar Datasets

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