Ontology highlight
ABSTRACT:
SUBMITTER: Sampson JH
PROVIDER: S-EPMC3943170 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Sampson John H JH Choi Bryan D BD Sanchez-Perez Luis L Suryadevara Carter M CM Snyder David J DJ Flores Catherine T CT Schmittling Robert J RJ Nair Smita K SK Reap Elizabeth A EA Norberg Pamela K PK Herndon James E JE Kuan Chien-Tsun CT Morgan Richard A RA Rosenberg Steven A SA Johnson Laura A LA
Clinical cancer research : an official journal of the American Association for Cancer Research 20131218 4
<h4>Purpose</h4>Chimeric antigen receptor (CAR) transduced T cells represent a promising immune therapy that has been shown to successfully treat cancers in mice and humans. However, CARs targeting antigens expressed in both tumors and normal tissues have led to significant toxicity. Preclinical studies have been limited by the use of xenograft models that do not adequately recapitulate the immune system of a clinically relevant host. A constitutively activated mutant of the naturally occurring ...[more]