Ontology highlight
ABSTRACT:
SUBMITTER: van Impel A
PROVIDER: S-EPMC3943180 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
van Impel Andreas A Zhao Zhonghua Z Hermkens Dorien M A DM Roukens M Guy MG Fischer Johanna C JC Peterson-Maduro Josi J Duckers Henricus H Ober Elke A EA Ingham Philip W PW Schulte-Merker Stefan S
Development (Cambridge, England) 20140212 6
In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. Its restricted expression in a subset of cardinal vein cells leads to a switch towards lymphatic specification and hence represents a prerequisite for the initiation of lymphangiogenesis. Murine Prox1-null embryos lack lymphatic structures, and sustained expression of Prox1 is indispensable for the maintenance of lymphatic cell fate even at adult stages, highlighting the unique importance ...[more]