Dataset Information
Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS.
Ontology highlight
ABSTRACT: Background
Polycystic ovary syndrome (PCOS) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology.Objective
We examined the possible association of adiponectin and insulin receptor gene polymorphisms with PCOS.Materials and methods
A total of 186 women with PCOS using NIH criteria and 156 healthy women were recruited. Their samples were genotyped for the polymorphism in exon 17 and 8 of the insulin receptor gene or exon and intron 2 of the adiponectin gene.Results
The distributions of genotypes and alleles of both polymorphisms were not different in women with PCOS and controls. There was no significant differences on the anthropometric and hormonal profiles of various adiponectin and insulin receptor genes polymorphisms among both groups.Conclusion
Adiponectin and insulin receptor gene polymorphisms are not associated with PCOS in a sample of Iranian population.
SUBMITTER: Ramezani Tehrani F
PROVIDER: S-EPMC3943219 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS.
Iranian journal of reproductive medicine 20130301 3
<h4>Background</h4>Polycystic ovary syndrome (PCOS) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology.<h4>Objective</h4>We examined the possible association of adiponectin and insulin receptor gene polymorphisms with PCOS.<h4>Materials and methods</h4>A total of 186 women with PCOS using NIH criteria and 156 healthy women were recruited. Their samples were genotyped for ...[more]