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Maternal OGTT glucose levels at 26-30 gestational weeks with offspring growth and development in early infancy.

ABSTRACT: AIMS: We aim to evaluate the association of maternal gestational oral glucose tolerance test (OGTT) glucose concentrations with anthropometry in the offspring from birth to 12 months in Tianjin, China. METHODS: A total of 27,157 pregnant women underwent OGTT during 26-30 weeks gestation, and their children had body weight/length measured from birth to 12 months old. RESULTS: Maternal OGTT glucose concentrations at 26-30 gestational weeks were positively associated with Z-scores for birth length-for-gestational age and birth weight-for-length. Compared with infants born to mothers with normal glucose tolerance, infants born to mothers with gestational diabetes mellitus (impaired glucose tolerance/new diabetes) had higher mean values of Z-scores for birth length-for-gestational age (0.07/0.23; normal group -0.08) and birth weight-for-length (0.27/0.57; normal group -0.001), smaller changes in mean values of Z-scores for length-for-age (0.75/0.62; normal group 0.94) and weight-for-length (0.18/-0.17; normal group 0.37) from birth to month 3, and bigger changes in mean values in Z-scores for weight-for-length (0.07/0.12; normal group 0.02) from month 9 to 12. CONCLUSIONS: Abnormal maternal glucose tolerance during pregnancy was associated with higher birth weight and birth length, less weight and length gain in the first 3 months of life, and more weight gain in the months 9-12 of life.

SUBMITTER: Liu G

PROVIDER: S-EPMC3943263 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Maternal OGTT glucose levels at 26-30 gestational weeks with offspring growth and development in early infancy.

Liu Gongshu G Li Nan N Sun Shurong S Wen Jing J Lyu Fengjun F Gao Wen W Li Lili L Chen Fang F Baccarelli Andrea A AA Hou Lifang L Hu Gang G

BioMed research international 20140213

<h4>Aims</h4>We aim to evaluate the association of maternal gestational oral glucose tolerance test (OGTT) glucose concentrations with anthropometry in the offspring from birth to 12 months in Tianjin, China.<h4>Methods</h4>A total of 27,157 pregnant women underwent OGTT during 26-30 weeks gestation, and their children had body weight/length measured from birth to 12 months old.<h4>Results</h4>Maternal OGTT glucose concentrations at 26-30 gestational weeks were positively associated with Z-score ...[more]

PMID: 24689042

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Project description:ObjectiveGestational diabetes mellitus (GDM) affects a significant number of women. Evidence regarding the association between GDM and offspring body mass index (BMI) is unclear due to small samples and lack of adequate confounding control. The objective of this study was to investigate the association between GDM and offspring BMI z-scores from birth to early adolescence and to examine the role of maternal pre-gestational BMI in this relationship.DesignProspective study.SettingPelotas 2004 Birth Cohort, Brazil.ParticipantsCohort participants that were followed-up from birth up to early adolescence (~3500) and their mothers.Primary outcome measuresBMI z-scores at birth, 3, 12, 24, 48 months and 6 and 11 years of age, calculated according to the WHO growth charts.ResultsUnadjusted and adjusted linear regressions were performed and interaction terms between maternal pre-gestational BMI and GDM were included. Prevalence of self-reported GDM was 2.6% (95% CI 2.1% to 3.1%). The offspring BMI z-scores (SD) at birth, 3, 12, 24, 48 months and at 6 and 11 years were 0.10 (1.12), -0.47 (1.10), 0.59 (1.10), 0.59 (1.08), 0.78 (1.32), 0.70 (1.43) and 0.75 (1.41), respectively. Unadjusted regression models showed positive associations between GDM and offspring BMI z-scores at birth, 6 and 11 years. After adjustment, the associations attenuated towards the null. Statistical evidence of effect modification between maternal pre-gestational BMI and GDM was observed at birth (p=0.007), with the association between GDM and offspring BMI z-score being apparent only in those children born to overweight or obese mothers (β=0.72, 95% CI 0.30 to 1.14 and β=0.61, 95% CI 0.20 to 1.01, respectively).ConclusionsWe observed that in the association between GDM and offspring BMI z-scores, there is a predominant role for maternal nutritional status before pregnancy and that the association between GDM and newborn's BMI is apparent only among those born to overweight or obese mothers.

Dataset Information

Maternal OGTT glucose levels at 26-30 gestational weeks with offspring growth and development in early infancy.

Publications

Maternal OGTT glucose levels at 26-30 gestational weeks with offspring growth and development in early infancy.

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