Sex- and age-interacting eQTLs in human complex diseases.
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ABSTRACT:
SUBMITTER: Yao C
PROVIDER: S-EPMC3943525 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Sex- and age-interacting eQTLs in human complex diseases.
Yao Chen C Joehanes Roby R Johnson Andrew D AD Huan Tianxiao T Esko Tõnu T Ying Saixia S Freedman Jane E JE Murabito Joanne J Lunetta Kathryn L KL Metspalu Andres A Munson Peter J PJ Levy Daniel D
Human molecular genetics 20131115 7
Many complex human diseases exhibit sex or age differences in gene expression. However, the presence and the extent of genotype-specific variations in gene regulation are largely unknown. Here, we report results of a comprehensive analysis of expression regulation of genetic variation related to 11,672 complex disease-associated SNPs as a function of sex and age in whole-blood-derived RNA from 5254 individuals. At false discovery rate <0.05, we identified 14 sex- and 10 age-interacting expressio ...[more]
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