Ontology highlight
ABSTRACT:
SUBMITTER: Lee H
PROVIDER: S-EPMC3943540 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lee Hewang H Abe Yoshifusa Y Lee Icksoo I Shrivastav Shashi S Crusan Annabelle P AP Hüttemann Maik M Hopfer Ulrich U Felder Robin A RA Asico Laureano D LD Armando Ines I Jose Pedro A PA Kopp Jeffrey B JB
Kidney international 20131016 3
Renal proximal tubule cells from spontaneously hypertensive rats (SHR), compared with normotensive Wistar-Kyoto rats (WKY), have increased oxidative stress. The contribution of mitochondrial oxidative phosphorylation to the subsequent hypertensive phenotype remains unclear. We found that renal proximal tubule cells from SHR, relative to WKY, had significantly higher basal oxygen consumption rates, adenosine triphosphate synthesis-linked oxygen consumption rates, and maximum and reserve respirati ...[more]