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Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells.


ABSTRACT: The first example of synchrotron X-ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine-labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.

SUBMITTER: Sheridan EJ 

PROVIDER: S-EPMC3943546 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells.

Sheridan Erin J EJ   Austin Christopher J D CJ   Aitken Jade B JB   Vogt Stefan S   Jolliffe Katrina A KA   Harris Hugh H HH   Rendina Louis M LM  

Journal of synchrotron radiation 20130207 Pt 2


The first example of synchrotron X-ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine-labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells. ...[more]

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