Exome sequencing and diffusion tensor imaging in developmental disabilities.
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ABSTRACT:
SUBMITTER: Sundaram S
PROVIDER: S-EPMC3943710 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Exome sequencing and diffusion tensor imaging in developmental disabilities.
Sundaram Senthil S Huq A H M AH Hsia Tammy T Chugani Harry H
Pediatric research 20131206 3
<h4>Background</h4>We had previously shown that arcuate fasciculus is poorly developed in patients with intellectual and developmental disabilities (IDD) using diffusion tensor imaging (DTI). In the present study, we used exome sequencing to identify the candidate variants in IDD patients with and without DTI abnormalities.<h4>Methods</h4>Eighteen children with IDD (age: 67 ± 36 mo, 9 females) were included in the present study. The DTI was used to determine the integrity of arcuate fasciculus. ...[more]
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