Follistatin interacts with Noggin in the development of the axial skeleton.
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ABSTRACT:
SUBMITTER: Stafford DA
PROVIDER: S-EPMC3943791 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Follistatin interacts with Noggin in the development of the axial skeleton.
Stafford David A DA Monica Stefanie D SD Harland Richard M RM
Mechanisms of development 20140201
When compared to single mutants for Follistatin or Noggin, we find that double mutants display a dramatic further reduction in trunk cartilage formation, particularly in the vertebral bodies and proximal ribs. Consistent with these observations, expression of the early sclerotome markers Pax1 and Uncx is diminished in Noggin;Follistatin compound mutants. In contrast, Sim1 expression expands medially in double mutants. As the onset of Follistatin expression coincides with sclerotome specification ...[more]
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