Unknown

Dataset Information

0

Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.


ABSTRACT: We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNF? and IL-1? to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months postvaccination, but these effects were less pronounced 1 year after vaccination. However, monocytes recovered 1 year after vaccination had an increased expression of pattern recognition receptors such as CD14, Toll-like receptor 4 (TLR4) and mannose receptor, and this correlated with an increase in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-?) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses.

SUBMITTER: Kleinnijenhuis J 

PROVIDER: S-EPMC3944069 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

altmetric image

Publications

Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.

Kleinnijenhuis Johanneke J   Quintin Jessica J   Preijers Frank F   Benn Christine Stabell CS   Joosten Leo A B LA   Jacobs Cor C   van Loenhout Joke J   Xavier Ramnik J RJ   Aaby Peter P   van der Meer Jos W M JW   van Crevel Reinout R   Netea Mihai G MG  

Journal of innate immunity 20131030 2


We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The  ...[more]

Similar Datasets

| S-EPMC7641012 | biostudies-literature
| S-EPMC7227382 | biostudies-literature
| S-EPMC7295478 | biostudies-literature
| S-EPMC7817864 | biostudies-literature
2021-01-27 | GSE159046 | GEO
| S-EPMC7832069 | biostudies-literature
| S-EPMC5177620 | biostudies-literature
| S-EPMC7267226 | biostudies-literature
| S-EPMC5919803 | biostudies-other
| S-EPMC9316941 | biostudies-literature