Gene-based GWAS and biological pathway analysis of the resilience of executive functioning.
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ABSTRACT:
SUBMITTER: Mukherjee S
PROVIDER: S-EPMC3944472 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Gene-based GWAS and biological pathway analysis of the resilience of executive functioning.
Mukherjee Shubhabrata S Kim Sungeun S Ramanan Vijay K VK Gibbons Laura E LE Nho Kwangsik K Glymour M Maria MM Ertekin-Taner Nilüfer N Montine Thomas J TJ Saykin Andrew J AJ Crane Paul K PK
Brain imaging and behavior 20140301 1
Resilience in executive functioning (EF) is characterized by high EF measured by neuropsychological test performance despite structural brain damage from neurodegenerative conditions. We previously reported single nucleotide polymorphism (SNP) genome-wide association study (GWAS) results for EF resilience. Here, we report gene- and pathway-based analyses of the same resilience phenotype, using an optimal SNP-set (Sequence) Kernel Association Test (SKAT) for gene-based analyses (conservative thre ...[more]
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