Ontology highlight
ABSTRACT:
SUBMITTER: Besse-Patin A
PROVIDER: S-EPMC3944655 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Besse-Patin Aurèle A Estall Jennifer L JL
International journal of cell biology 20140212
Oxidative stress damages multiple cellular components including DNA, lipids, and proteins and has been linked to pathological alterations in nonalcoholic fatty liver disease (NAFLD). Reactive oxygen species (ROS) emission, resulting from nutrient overload and mitochondrial dysfunction, is thought to be a principal mediator in NAFLD progression, particularly toward the development of hepatic insulin resistance. In the context of insulin signalling, ROS has a dual role, as both a facilitator and i ...[more]